Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.32 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.32 |
| ▸ | RPS17 | P08708 | 1/20 | 0.32 |
| ▸ | RPSA | P08865 | 1/20 | 0.32 |
| ▸ | RPS2 | P15880 | 1/20 | 0.32 |
| ▸ | RPL35A | P18077 | 1/20 | 0.32 |
| ▸ | RPL7 | P18124 | 1/20 | 0.32 |
| ▸ | RPL17 | P18621 | 1/20 | 0.32 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6590713 | 0.90 | PSEN1 (0.31) | ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL7428571 | 0.86 | RPLP1 (0.33) | KCNH2RPLP1RPLP0RPS17RPSA | |
| SCHEMBL6586366 | 0.83 | SLC6A2 (0.31) | SLC6A2SLC6A4 | |
| SCHEMBL4763307 | 0.82 | PSEN1 (0.32) | KMT2AMEN1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4765027 | 0.80 | CTSD (0.45) | SLC6A2SLC6A4KCNH2SLC6A3CYP2D6 | |
| SCHEMBL6590138 | 0.80 | KMT2A (0.38) | KMT2ASLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL6589694 | 0.79 | SIGMAR1 (0.34) | SIGMAR1KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL6589570 | 0.78 | — | — | |
| SCHEMBL6594374 | 0.74 | RPLP1 (0.39) | KCNH2RPLP1RPLP0RPS17RPSA | |
| SCHEMBL6590526 | 0.73 | REN (0.32) | SLC6A2SLC6A4KCNH2SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307204-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1307204-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2001095911-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |