Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.44 |
| ▸ | DHODH | Q02127 | 6/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6592858 | 0.78 | EGLN1 (0.43) | EGLN1MAPK14DHODHMAPK10MAPK13 | |
| SCHEMBL13118742 | 0.75 | GCGR (0.50) | EGLN1MAPK14MAPK10MAPK13GCGR | |
| SCHEMBL12888433 | 0.75 | RAB9A (0.44) | MAPK14ALOX5GCGRALDH1A1KDM4E | |
| SCHEMBL6587607 | 0.74 | KIT (0.41) | MAPK14DHODHALDH1A1KDM4ELMNA | |
| SCHEMBL7557523 | 0.71 | GCGR (0.47) | EGLN1MAPK14DHODHGCGR | |
| SCHEMBL11709927 | 0.71 | ADORA2A (0.56) | EGLN1MAPK14MAPK10ALDH1A1MAP2K2 | |
| SCHEMBL5420904 | 0.70 | ADORA3 (0.43) | MAPK14ALOX5ALDH1A1KDM4EHPGD | |
| SCHEMBL13118740 | 0.69 | GCGR (0.51) | GCGR | |
| SCHEMBL10410199 | 0.69 | EGLN1 (0.48) | EGLN1DHODHKDM4E | |
| SCHEMBL18057352 | 0.69 | PIK3CA (0.44) | DHODHMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781766-B1 | HETEROCYCLIC DERIVATIVE AND MEDICINE | NIPPON SHINYAKU CO LTD (JP) | 2004-03-31 | — | — | EP | disclosed |
| CN-1118454-C | Heterocyclic derivative and medicine | NIPPON SHINYAKU CO LTD (JP) | 2003-08-20 | — | — | CN | disclosed |
| US-6191149-B1 | DRUG FOR CEREBROVASCULAR DISEASE | NIPPON SHINYAKU, CO., LTD. (JP) | 2001-02-20 | — | — | US | disclosed |
| US-5945426-A | PREVENT NEURONAL DEATH | NIPPON SHINYAKU CO., LTD. (JP) | 1999-08-31 | — | — | US | disclosed |
| CN-1157609-A | Heterocyclic derivative and medicine | NIPPON SHINYAKU CO LTD (JP) | 1997-08-20 | — | — | CN | disclosed |
| EP-0781766-A1 | HETEROCYCLIC DERIVATIVE AND MEDICINE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1997-07-02 | — | — | EP | disclosed |