Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 5/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 3/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6593138 | 0.89 | CTSL (0.31) | CTSLCTSBCTSKCTSS | |
| SCHEMBL7386818 | 0.88 | — | — | |
| SCHEMBL4763320 | 0.87 | CTSL (0.37) | CTSLMAPK14CTSBCTSKCTSS | |
| SCHEMBL6896141 | 0.84 | MAPK1 (0.32) | CTSLCTSBCTSKCTSS | |
| SCHEMBL4765376 | 0.76 | CTSK (0.31) | CTSLCTSBCTSKCTSS | |
| SCHEMBL6211401 | 0.76 | CTSK (0.37) | CTSLCTSBCTSKCTSS | |
| SCHEMBL6590804 | 0.75 | CTSL (0.31) | CTSLCTSKCTSS | |
| SCHEMBL4767192 | 0.75 | TAS1R3 (0.44) | — | |
| SCHEMBL6589335 | 0.75 | — | — | |
| SCHEMBL4766715 | 0.74 | CTSK (0.37) | CTSLCTSBCTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307204-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1307204-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2001095911-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |