Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | CD44 | P16070 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7829502 | 0.80 | ALDH1A1 (0.39) | CYP3A4TSHRPIK3CAALDH1A1HSD17B10 | |
| SCHEMBL23261662 | 0.79 | AHR (0.47) | ALDH1A1TDP1HPGDNR4A2RAB9A | |
| SCHEMBL15046889 | 0.78 | MCL1 (0.56) | TSHRALDH1A1HSD17B10ELANEMCL1 | |
| SCHEMBL7815658 | 0.77 | CYP3A4 (0.40) | CYP3A4TSHRPIK3CAALDH1A1HSD17B10 | |
| SCHEMBL24254913 | 0.77 | ALDH1A1 (0.55) | CYP3A4TSHRPIK3CAALDH1A1HSD17B10 | |
| SCHEMBL23938618 | 0.76 | CYP3A4 (0.35) | CYP3A4TSHRPIK3CAALDH1A1HSD17B10 | |
| SCHEMBL7826135 | 0.76 | ALDH1A1 (0.35) | CYP3A4TSHRPIK3CAALDH1A1HSD17B10 | |
| SCHEMBL6454090 | 0.75 | MAOA (0.46) | TSHRHSD17B10TDP1HPGDMCL1 | |
| SCHEMBL8038421 | 0.75 | LOXL2 (0.40) | TSHRALDH1A1HSD17B10HPGDMCL1 | |
| SCHEMBL7828174 | 0.74 | CYP3A4 (0.34) | CYP3A4TSHRPIK3CAALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1293075-C | Indole and 2,3-indoline derivative, their preparation and application | LUNDBECK & CO AS H (DK) | 2007-01-03 | — | — | CN | disclosed |
| CN-1286833-C | Indole and 2,3-indoline derivative, their preparation and application | LUNDBECK & CO AS H (DK) | 2006-11-29 | — | — | CN | disclosed |
| EP-1007523-B9 | INDOLE AND 2,3-DIHYDROINDOLE DERIVATIVES, THEIR PREPARATION AND USE | LUNDBECK & CO AS H (DK) | 2004-09-08 | — | — | EP | disclosed |
| CN-1515568-A | Indole and 2,3-indoline derivative, their preparation and application | H.隆德贝克有限公司 | 2004-07-28 | — | — | CN | disclosed |
| CN-1515569-A | Indole and 2,3-indoline derivative, their preparation and application | H.隆德贝克有限公司 | 2004-07-28 | — | — | CN | disclosed |
| US-6727263-B2 | SEROTONINE REUPTAKE INHIBITOR; ANTIDEPRESSANTS; SIDE EFFECT REDUCTION | H. LUNDBECK A/S (DK) | 2004-04-27 | — | — | US | disclosed |
| CN-1127501-C | indole and 2, 3-indoline derivatives, their preparation and use | LUNDBECK & CO AS H (DK) | 2003-11-12 | — | — | CN | disclosed |
| EP-1007523-B1 | INDOLE AND 2,3-DIHYDROINDOLE DERIVATIVES, THEIR PREPARATION AND USE | LUNDBECK & CO AS H (DK) | 2003-10-22 | — | — | EP | disclosed |
| CN-1414963-A | novel heteroaryl derivatives, their preparation and use | LUNDBECK & CO AS H (DK) | 2003-04-30 | — | — | CN | disclosed |
| US-20030050306-A1 | Novel heteroaryl derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2003-03-13 | — | — | US | disclosed |
| US-6476035-B1 | Indole and 2,3-dihydroindole derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-11-05 | — | — | US | disclosed |
| EP-1246820-A1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001049683-A1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2001-07-12 | — | — | WO | disclosed |
| EP-0757682-B1 | BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-06-20 | — | — | EP | disclosed |
| CN-1265107-A | indole and 2, 3-indoline derivatives, their preparation and use | LUNDBECK & CO AS H (DK) | 2000-08-30 | — | — | CN | disclosed |
| EP-1007523-A1 | INDOLE AND 2,3-DIHYDROINDOLE DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999005140-A1 | INDOLE AND 2,3-DIHYDROINDOLE DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 1999-02-04 | — | — | WO | disclosed |
| US-5858995-A | ADMINISTERING TO HUMANS AND ANIMALS IN THE TREATMENT OF DISEASES CAUSED BY ABNORMAL BONE METABOLISM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-01-12 | — | — | US | disclosed |
| EP-0757682-A1 | BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029907-A1 | BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030050306-A1 | Novel heteroaryl derivatives, their preparation and use | CRBN, CDR2, DRD3 | CYP3A4 913/4885TSHR 137/4885PIK3CA 4673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.