Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6591980 | 0.92 | ICMT (0.37) | PIM1CAMK2DPLK1ICMTPTGDR2 | |
| Trifluoroacetic Acid SCHEMBL6586877 | 0.92 | ICMT (0.38) | PIM1CAMK2DPLK1ICMTPTGDR2 | |
| Trifluoroacetic Acid SCHEMBL6590532 | 0.90 | CDK2 (0.38) | PIM1CAMK2DPLK1ICMTPTGDR2 | |
| Trifluoroacetic Acid SCHEMBL6588330 | 0.90 | CAMK2D (0.43) | PIM1CAMK2DPLK1PTGDR2GSK3B | |
| Trifluoroacetic Acid SCHEMBL6585782 | 0.90 | CAMK2D (0.45) | PIM1CAMK2DPTGDR2CDK2HSP90AA1 | |
| Trifluoroacetic Acid SCHEMBL6588425 | 0.90 | HTR6 (0.39) | PLK1PTGDR2GSK3BCDK2HSP90AA1 | |
| Trifluoroacetic Acid SCHEMBL6591483 | 0.89 | GSK3B (0.37) | PIM1CAMK2DPLK1GSK3B | |
| Trifluoroacetic Acid SCHEMBL6585732 | 0.88 | PLK1 (0.35) | PIM1CAMK2DPLK1ICMTPTGDR2 | |
| SCHEMBL6588981 | 0.88 | CAMK2D (0.42) | PIM1CAMK2DPLK1ICMTGSK3B | |
| Hydrochloric Acid SCHEMBL6588778 | 0.88 | CAMK2D (0.42) | PIM1CAMK2DPLK1ICMTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1183252-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071537-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-30 | — | — | WO | disclosed |