Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2439783 | 0.81 | POLB (0.47) | ALDH1A1KMT2AMEN1CHRM1CNR1 | |
| SCHEMBL4002045 | 0.79 | POLB (0.45) | ALDH1A1KMT2AMEN1CHRM1CNR1 | |
| SCHEMBL1020294 | 0.79 | P2RX7 (0.51) | KMT2ACHRM1P2RX7 | |
| SCHEMBL7498303 | 0.78 | POLB (0.41) | ALDH1A1KMT2AMEN1CHRM1CNR1 | |
| SCHEMBL1020902 | 0.78 | P2RX7 (0.53) | KMT2AMEN1CHRM1CNR1P2RX7 | |
| SCHEMBL1019257 | 0.78 | P2RX7 (0.53) | KMT2AMEN1CHRM1CNR1P2RX7 | |
| SCHEMBL1018807 | 0.76 | IL1B (0.52) | KMT2ACHRM1CNR1L3MBTL1P2RX7 | |
| SCHEMBL1020264 | 0.76 | CHRM1 (0.42) | CHRM1P2RX7 | |
| SCHEMBL6586386 | 0.75 | NR4A2 (0.64) | ALDH1A1KMT2AMAPTNR4A2POLB | |
| SCHEMBL14772079 | 0.74 | ALDH1A1 (0.42) | ALDH1A1KMT2AMEN1SCN9ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1183252-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071537-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-30 | — | — | WO | disclosed |