SCHEMBL6593145

SCHEMBL6593145

C#Cc1c(C(=O)O)nc2c(C#N)cccc2c1OCc1ccccc1.c1cc2cc-2c1

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
XDH P47989 3/20 0.40
SQOR Q9Y6N5 1/20 0.38
ADORA1 P30542 1/20 0.37
NR4A2 P43354 1/20 0.36
FFAR1 O14842 1/20 0.36
MCL1 Q07820 1/20 0.36
CNR1 P21554 1/20 0.36
GABRG2 P18507 1/20 0.35
GABRB3 P28472 1/20 0.35
GABRA5 P31644 1/20 0.35
GABRA3 P34903 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL6592619 0.95 XDH (0.39) XDHNR4A2
SCHEMBL6080439 0.84 XDH (0.39) XDHSQORADORA1NR4A2
SCHEMBL6593140 0.83 XDH (0.38) XDHFFAR1MCL1
SCHEMBL6594157 0.81 XDH (0.40) XDHNR4A2
SCHEMBL6080303 0.80 KDM5B (0.36) XDHADORA1
Benzene SCHEMBL6079490 0.78 XDH (0.41) XDH
Benzene SCHEMBL6595147 0.77 PIN1 (0.39)
SCHEMBL6079921 0.76 MRGPRX4 (0.41) ADORA1
SCHEMBL6080436 0.75 ADORA3 (0.41) XDHFFAR1
SCHEMBL6080478 0.74 XDH (0.39) XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1451159-A1 COMPOSITIONS DERIVED FROM QUINOLINE AND QUINOXALINE, PREPARATION AND USE THEREOF NEURO3D (FR) 2004-09-01 EP claimed
WO-2003010146-A1 COMPOSITIONS DERIVED FROM QUINOLINE AND QUINOXALINE, PREPARATION AND USE THEREOF NEURO3D (FR) 2003-02-06 WO claimed
EP-1451159-A1 COMPOSITIONS DERIVED FROM QUINOLINE AND QUINOXALINE, PREPARATION AND USE THEREOF NEURO3D (FR) 2004-09-01 EP disclosed
WO-2003010146-A1 COMPOSITIONS DERIVED FROM QUINOLINE AND QUINOXALINE, PREPARATION AND USE THEREOF NEURO3D (FR) 2003-02-06 WO disclosed