Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 6/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 5/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR1F | P30939 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6594584 | 0.92 | UTS2R (0.62) | UTS2RSIGMAR1DRD4DRD2HTR1A | |
| SCHEMBL17152608 | 0.86 | BACE1 (0.53) | SIGMAR1DRD4DRD2HTR2CHTR2B | |
| SCHEMBL6594030 | 0.83 | UTS2R (0.57) | UTS2RSIGMAR1DRD4DRD2HTR1A | |
| SCHEMBL17152266 | 0.82 | SIGMAR1 (0.56) | SIGMAR1DRD4DRD2HTR2CHTR2B | |
| SCHEMBL6597043 | 0.82 | UTS2R (0.62) | UTS2RDRD2HTR1ACYP2D6HTR1D | |
| SCHEMBL6597270 | 0.81 | UTS2R (0.61) | UTS2RDRD2HTR1ACYP2D6HTR1D | |
| SCHEMBL6597839 | 0.79 | UTS2R (0.62) | UTS2RDRD2HTR1ACYP2D6HTR1D | |
| SCHEMBL6983020 | 0.76 | UTS2R (0.45) | UTS2R | |
| SCHEMBL17152243 | 0.75 | SIGMAR1 (0.59) | SIGMAR1CCR3CYP2D6 | |
| SCHEMBL17152224 | 0.75 | SIGMAR1 (0.58) | SIGMAR1DRD4DRD2HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246619-B1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-10-20 | — | — | EP | claimed |
| US-6514970-B1 | Pyrrolidines such as benzo(b)thiophene-2-carboxylic acid ((S)-1-((S)-1-(4-(1-benzyl-piperidin-4-yloxy)-3-chloro-benzyl)-pyrrolidin-3 -ylcarbamoyl)-3- methyl-butyl)-amide | SMITHKLINE BEECHAM CORPORATION | 2003-02-04 | — | — | US | claimed |
| EP-1246619-B1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-10-20 | — | — | EP | disclosed |
| US-6514970-B1 | Pyrrolidines such as benzo(b)thiophene-2-carboxylic acid ((S)-1-((S)-1-(4-(1-benzyl-piperidin-4-yloxy)-3-chloro-benzyl)-pyrrolidin-3 -ylcarbamoyl)-3- methyl-butyl)-amide | SMITHKLINE BEECHAM CORPORATION | 2003-02-04 | — | — | US | disclosed |