Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | UBE2M | P61081 | 1/20 | 0.51 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.51 |
| ▸ | CCR3 | P51677 | 3/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17152266 | 0.88 | SIGMAR1 (0.56) | SIGMAR1KCNH2POLBKMT2A | |
| SCHEMBL17152595 | 0.82 | SIGMAR1 (0.56) | SIGMAR1ALDH1A1KMT2ACHRM2CHRM1 | |
| SCHEMBL17152546 | 0.82 | SIGMAR1 (0.54) | SIGMAR1KCNH2CHRM2CHRM1CHRM3 | |
| SCHEMBL17152608 | 0.82 | BACE1 (0.53) | SIGMAR1MCHR1 | |
| SCHEMBL17152224 | 0.80 | SIGMAR1 (0.58) | SIGMAR1 | |
| SCHEMBL17152474 | 0.79 | SLC6A12 (0.48) | SIGMAR1KCNH2MCHR1UBE2MDCUN1D1 | |
| SCHEMBL17152245 | 0.79 | SIGMAR1 (0.62) | SIGMAR1KCNH2MCHR1ALDH1A1POLB | |
| SCHEMBL17152373 | 0.77 | OPRM1 (0.55) | SIGMAR1ALDH1A1POLBCHRM2CHRM1 | |
| SCHEMBL17152404 | 0.76 | SMN1; SMN2 (0.43) | ALDH1A1KMT2AUBE2MDCUN1D1 | |
| SCHEMBL6594029 | 0.75 | UTS2R (0.55) | SIGMAR1CCR3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897939-B1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES FOR TREATING METABOLIC OR CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2017-02-01 | — | — | EP | disclosed |
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | disclosed |