Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 11/20 | 0.53 |
| ▸ | DRD2 | P14416 | 10/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17152266 | 0.94 | SIGMAR1 (0.56) | DRD4DRD2SIGMAR1HTR2AHTR2C | |
| SCHEMBL17152224 | 0.87 | SIGMAR1 (0.58) | DRD4DRD2SIGMAR1HTR2AHTR2C | |
| SCHEMBL6594029 | 0.86 | UTS2R (0.55) | BACE1DRD4DRD2SIGMAR1HTR2C | |
| SCHEMBL6594584 | 0.85 | UTS2R (0.62) | DRD4DRD2SIGMAR1HTR2CHTR2B | |
| SCHEMBL17152344 | 0.83 | DRD2 (0.51) | DRD4DRD2 | |
| SCHEMBL17152546 | 0.83 | SIGMAR1 (0.54) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL4689693 | 0.83 | ALDH1A1 (0.45) | DRD4DRD2 | |
| SCHEMBL17152595 | 0.82 | SIGMAR1 (0.56) | DRD4DRD2SIGMAR1HTR2AHTR2C | |
| SCHEMBL17152243 | 0.82 | SIGMAR1 (0.59) | MCHR1SIGMAR1 | |
| SCHEMBL6595055 | 0.82 | UTS2R (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | disclosed |