Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 8/20 | 0.59 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.57 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.57 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 4/20 | 0.53 |
| ▸ | EBP | Q15125 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8003918 | 0.95 | LTA4H (0.60) | LTA4HPSMB1PSMB5PSMB2ESR1 | |
| SCHEMBL8015671 | 0.85 | EBP (0.67) | LTA4HPSMB1PSMB5PSMB2ESR1 | |
| SCHEMBL6592276 | 0.80 | ESR1 (0.76) | LTA4HPSMB1PSMB5PSMB2ESR1 | |
| SCHEMBL8003921 | 0.80 | EBP (0.78) | LTA4HESR1EBPSIGMAR1HRH3 | |
| SCHEMBL7442242 | 0.78 | LTA4H (0.69) | LTA4HPSMB1PSMB5PSMB2HRH3 | |
| SCHEMBL7581591 | 0.77 | LTA4H (0.61) | LTA4HPSMB1PSMB5PSMB2ESR1 | |
| SCHEMBL7576301 | 0.77 | ESR1 (0.74) | PSMB1PSMB5PSMB2ESR1ESR2 | |
| SCHEMBL6595870 | 0.77 | ESR1 (0.83) | LTA4HPSMB1PSMB5PSMB2ESR1 | |
| SCHEMBL11179589 | 0.77 | ESR1 (0.83) | LTA4HPSMB1PSMB5PSMB2ESR1 | |
| SCHEMBL8504413 | 0.76 | EBP (0.64) | LTA4HPSMB1PSMB5PSMB2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863755-B1 | ANTITHROMBOTIC DIAMINES | LILLY CO ELI (US) | 2004-12-15 | — | — | EP | disclosed |
| US-6265575-B1 | THROMBIN INHIBITORS | ELI LILLY AND COMPANY | 2001-07-24 | — | — | US | disclosed |
| US-6251921-B1 | ADMINISTERING THROMBIN INHIBITING DIAMINE COMPOUND TO MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-6025382-A | Antithrombotic diamines | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |