Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 3/20 | 0.55 |
| ▸ | CCR2 | P41597 | 13/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6597658 | 0.91 | ABCB11 (0.67) | ABCB11CCR2 | |
| SCHEMBL7083186 | 0.85 | MAPT (0.43) | ABCB11CCR2MAPTALDH1A1GAA | |
| SCHEMBL6785298 | 0.82 | ABCB11 (0.76) | ABCB11CCR2MAPT | |
| SCHEMBL3297082 | 0.79 | MAPT (0.53) | MAPTALDH1A1GAAPKMTHRB | |
| SCHEMBL4252125 | 0.79 | MAPT (0.53) | MAPTALDH1A1GAAPKMTHRB | |
| SCHEMBL6594667 | 0.78 | CCR2 (0.61) | ABCB11CCR2MAPT | |
| SCHEMBL6595450 | 0.77 | CCR2 (0.50) | ABCB11CCR2MAPTGAA | |
| SCHEMBL6302533 | 0.76 | CCR2 (0.63) | ABCB11CCR2MAPTKMT2A | |
| SCHEMBL6591954 | 0.76 | CCR2 (0.55) | ABCB11CCR2MAPTKMT2A | |
| SCHEMBL6600137 | 0.75 | CCR2 (0.57) | ABCB11CCR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150952-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-10-27 | — | — | EP | disclosed |
| US-6737435-B1 | ANTIINFLAMMATORY AGENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DISEASES | ASTRAZENECA AB (SE) | 2004-05-18 | — | — | US | disclosed |
| EP-1150952-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046196-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |