Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 14/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.48 |
| ▸ | EDNRB | P24530 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083189 | 0.84 | EDNRB (0.43) | EDNRBEDNRAS1PR1S1PR5MRGPRX4 | |
| SCHEMBL6785303 | 0.82 | ABCB11 (0.61) | CCR2ABCB11 | |
| SCHEMBL6597658 | 0.80 | ABCB11 (0.67) | CCR2ABCB11 | |
| SCHEMBL6780034 | 0.80 | CCR2 (0.61) | CCR2ABCB11EDNRBEDNRALMNA | |
| SCHEMBL6595449 | 0.77 | ABCB11 (0.55) | CCR2ABCB11GAAMAPT | |
| SCHEMBL6307042 | 0.74 | CCR2 (0.77) | CCR2ABCB11LMNAGAAMAPT | |
| SCHEMBL8065427 | 0.72 | CCR2 (0.52) | CCR2ABCB11 | |
| SCHEMBL6598122 | 0.72 | ABCB11 (0.74) | CCR2ABCB11GAAMAPT | |
| SCHEMBL6595115 | 0.69 | ABCB11 (0.55) | CCR2ABCB11EDNRBEDNRA | |
| SCHEMBL1495326 | 0.68 | MRGPRX4 (0.54) | SMN1; SMN2MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150952-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-10-27 | — | — | EP | disclosed |
| US-6737435-B1 | ANTIINFLAMMATORY AGENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DISEASES | ASTRAZENECA AB (SE) | 2004-05-18 | — | — | US | disclosed |
| EP-1150952-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046196-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |