Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUSP3 | P51452 | 3/20 | 0.49 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18828601 | 0.81 | ALDH1A1 (0.44) | DUSP3PTPN5PTPN11CYP1A2CYP3A4 | |
| SCHEMBL22340249 | 0.78 | HPGD (0.37) | L3MBTL1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL22643223 | 0.77 | HPGD (0.36) | L3MBTL1SMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL3773093 | 0.72 | DPP4 (0.34) | — | |
| SCHEMBL20310914 | 0.70 | KDM4E (0.34) | SMN1; SMN2KDM4E | |
| SCHEMBL5257237 | 0.69 | ALDH1A1 (0.69) | DUSP3PTPN5PTPN11CYP1A2CYP3A4 | |
| SCHEMBL578273 | 0.69 | GAA (0.67) | DUSP3PTPN5PTPN11CYP1A2CYP3A4 | |
| SCHEMBL21613823 | 0.68 | DHCR7 (0.39) | CYP2D6L3MBTL1HTTGAATP53 | |
| SCHEMBL17402954 | 0.68 | TSHR (0.33) | MAPT | |
| SCHEMBL3783625 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414801-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003004472-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |