Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22340249 | 0.98 | HPGD (0.37) | HPGDRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL18828601 | 0.81 | ALDH1A1 (0.44) | RAB9AALDH1A1SMN1; SMN2NPC1LMNA | |
| SCHEMBL12169282 | 0.80 | KMT2A (0.39) | HPGDRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL14538645 | 0.80 | KMT2A (0.39) | HPGDRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3773093 | 0.79 | DPP4 (0.34) | — | |
| SCHEMBL1259047 | 0.79 | KCNH2 (0.38) | HPGDALDH1A1LMNASIGMAR1 | |
| SCHEMBL20919908 | 0.79 | KCNH2 (0.38) | HPGDALDH1A1LMNASIGMAR1 | |
| SCHEMBL12406349 | 0.78 | PKM (0.38) | RAB9AALDH1A1SMN1; SMN2NPC1FKBP1A | |
| SCHEMBL19313630 | 0.78 | ALDH1A1 (0.41) | RAB9AALDH1A1NPC1USP2LMNA | |
| SCHEMBL20195364 | 0.77 | KCNH2 (0.35) | HPGDALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970283-B1 | SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2020-11-11 | — | — | EP | disclosed |