SCHEMBL6596167

SCHEMBL6596167

Cc1c(-c2cc3cc(N4C(=O)CCC4=O)ccc3o2)oc(=O)c(C)c1O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.36
GLA P06280 1/20 0.34
LMNA P02545 3/20 0.34
KMT2A Q03164 4/20 0.33
ALDH1A1 P00352 3/20 0.33
KDM4E B2RXH2 2/20 0.33
MEN1 O00255 2/20 0.33
PKM P14618 2/20 0.33
HPGD P15428 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HSD17B10 Q99714 1/20 0.33
TP53 P04637 1/20 0.32
GAA P10253 1/20 0.32
ALOX15 P16050 1/20 0.32
TSHR P16473 1/20 0.32
ATM Q13315 1/20 0.32
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA9 Q16790 1/20 0.31
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6594753 0.95 KMT2A (0.39) L3MBTL1GLALMNAKMT2AALDH1A1
SCHEMBL6591434 0.82 SLC16A3 (0.43) L3MBTL1LMNAKMT2AALDH1A1KDM4E
SCHEMBL6593518 0.80 ESR1 (0.50) GLALMNAALDH1A1KDM4EHPGD
SCHEMBL6592579 0.78 FLT3 (0.44) KDM4EMAOBMAOAESR1ESR2
SCHEMBL6592852 0.78 LMNA (0.34) LMNAALDH1A1KDM4EHPGDMAOA
SCHEMBL27535023 0.76 SLC6A2 (0.33)
SCHEMBL6597257 0.76 KDM4E (0.50) L3MBTL1LMNAKMT2AALDH1A1KDM4E
SCHEMBL6592885 0.76 CHRM2 (0.42) KDM4ECA12CA1CA9MAOB
SCHEMBL6594401 0.76 APP (0.48) L3MBTL1KDM4EESR1ESR2
SCHEMBL6589075 0.76 KDM4E (0.50) ALDH1A1KDM4EHPGDSMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1063235-B1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LTD (JP) 2004-05-12 EP disclosed
US-20030186976-A1 Benzofurylpyrone derivatives TEIJIN LIMITED, MICROBIAL CHEMISTRY RESEARCH FOUNDATION 2003-10-02 US disclosed
US-6589984-B1 Blood cholesterol and triglycerides (TG) themselves are generally insoluble in blood, and they exist as lipoproteins by binding with apolipoproteins. In the body, triglycerides are biosynthesized primarily in the liver from acetyl CoA as TEIJIN LIMITED (JP) 2003-07-08 US disclosed
EP-1063235-A1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LIMITED (JP) 2000-12-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030186976-A1 Benzofurylpyrone derivatives PLIN5, ACSL5, PLIN1 L3MBTL1 2392/4885GLA 937/4885LMNA 2644/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.