Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1097809 | 0.81 | SGMS2 (0.59) | HTTSGMS2NPC1GAAMAPT | |
| SCHEMBL9642440 | 0.81 | SGMS2 (0.59) | HTTSGMS2NPC1GAAMAPT | |
| SCHEMBL8827709 | 0.79 | SGMS2 (0.56) | HTTSGMS2NPC1PARP1GAA | |
| SCHEMBL9731418 | 0.79 | SGMS2 (0.50) | HTTSGMS2NPC1PARP1GAA | |
| SCHEMBL6938166 | 0.72 | SGMS2 (0.58) | HTTSGMS2NPC1GAAMAPT | |
| SCHEMBL10443318 | 0.72 | SGMS2 (0.58) | HTTSGMS2NPC1GAAMAPT | |
| SCHEMBL9231981 | 0.71 | SGMS2 (0.54) | HTTSGMS2NPC1PARP1GAA | |
| SCHEMBL712291 | 0.71 | SGMS2 (0.57) | HTTSGMS2NPC1GAAMAPT | |
| SCHEMBL7164705 | 0.71 | SGMS2 (0.57) | HTTSGMS2NPC1GAAMAPT | |
| SCHEMBL316291 | 0.71 | SGMS2 (0.53) | HTTSGMS2NPC1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150954-B1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-10-13 | — | — | EP | disclosed |
| US-6569888-B1 | Such as ethyl-N-(dichlorobenzyl)-4-(3-hydroxypropylthio) indole-2-carboxylate; for treatment of arthritis | ASTRAZENECA AB (SE) | 2003-05-27 | — | — | US | disclosed |