Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6596513 | 0.80 | RAB9A (0.43) | RAB9APOLBMAPTNPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5365087 | 0.80 | KMT2A (0.42) | RAB9APOLBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL6598001 | 0.74 | ALDH1A1 (0.38) | RAB9APOLBMAPTNPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3686641 | 0.66 | ALDH1A1 (0.38) | RAB9APOLBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL297726 | 0.65 | MAPT (0.38) | RAB9APOLBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL287109 | 0.65 | MAPT (0.37) | RAB9APOLBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL17570209 | 0.63 | POLB (0.62) | RAB9APOLBMAPTSMN1; SMN2HCRTR1 | |
| Bromide SCHEMBL5975997 | 0.62 | ALDH1A1 (0.43) | RAB9APOLBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL1230353 | 0.62 | RAB9A (1.00) | RAB9APOLBMAPTNPC1ALOX15 | |
| SCHEMBL2662870 | 0.62 | RAB9A (0.70) | RAB9APOLBMAPTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373263-B1 | HETEROCYCLIC COMPOUNDS FOR AGING-RELATED AND DIABETIC VASCULAR COMPLICATIONS | TORRENT PHARMACEUTICALS LTD (IN) | 2004-10-27 | — | — | EP | claimed |