Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6599927 | 0.86 | LMNA (0.34) | ALDH1A1SMN1; SMN2LMNARAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL6596513 | 0.84 | RAB9A (0.43) | ALDH1A1TSHRSMN1; SMN2LMNARAB9A | |
| SCHEMBL6598288 | 0.84 | ALDH1A1 (0.37) | ALDH1A1TSHRLMNAL3MBTL1HPGD | |
| Bromide SCHEMBL1194181 | 0.84 | ALDH1A1 (0.36) | ALDH1A1TSHRSMN1; SMN2LMNAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL6609904 | 0.81 | POLB (0.34) | ALDH1A1TSHRSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL6598001 | 0.81 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2LMNAL3MBTL1RAB9A | |
| Hydrochloric Acid SCHEMBL6611866 | 0.80 | POLB (0.38) | ALDH1A1SMN1; SMN2LMNARAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL6621921 | 0.80 | CPT2 (0.33) | ALDH1A1LMNARAB9ANPC1MEN1 | |
| Hydrochloric Acid SCHEMBL5358894 | 0.79 | MEN1 (0.38) | ALDH1A1SMN1; SMN2LMNARAB9AHPGD | |
| SCHEMBL6598655 | 0.78 | MEN1 (0.38) | ALDH1A1SMN1; SMN2LMNARAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254563-A2 | PHARMACEUTICAL COMBINATIONS COMPRISING SPECIFIED AGE BREAKER AND FURTHER DRUGS, I.A. ANTIHYPERTENSIVE DRUGS, ANTIDIABETIC DRUGS ETC | Torrent Pharmaceuticals Ltd. (IN) | 2010-12-01 | — | — | EP | claimed |
| WO-2009093264-A2 | PHARMACEUTICAL COMBINATIONS | TORRENT PHARMACEUTICALS LTD. (IN) | 2009-07-30 | — | — | WO | claimed |