Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447965 | 0.76 | HTT (0.35) | NPC1GMNNLMNATP53CYP1A2 | |
| SCHEMBL4027100 | 0.75 | LMNA (0.37) | LMNA | |
| SCHEMBL1448131 | 0.70 | TSHR (0.34) | NPC1GMNNLMNATP53CYP1A2 | |
| SCHEMBL6594480 | 0.68 | ALDH1A1 (0.34) | NPC1GMNNLMNATP53CYP1A2 | |
| SCHEMBL3551490 | 0.68 | TP53 (0.41) | LMNATP53HTTSMN1; SMN2NPSR1 | |
| SCHEMBL1447777 | 0.68 | MLYCD (0.40) | LMNAHTTNPSR1GPBAR1MLYCD | |
| SCHEMBL14662132 | 0.67 | NR1I2 (0.40) | LMNATP53CYP3A4ADORA2AADORA2B | |
| SCHEMBL1156106 | 0.67 | NPC1 (0.35) | NPC1GMNNLMNATP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL5245490 | 0.66 | CSF1R (0.33) | NPC1GMNNLMNATP53CYP1A2 | |
| SCHEMBL1447502 | 0.66 | HTT (0.40) | LMNATP53HTTGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |