Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 5/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.38 |
| ▸ | SLC9A2 | Q9UBY0 | 2/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314631 | 0.82 | NFE2L2 (0.64) | KEAP1NFE2L2MEN1KMT2ARBP4 | |
| SCHEMBL6312965 | 0.76 | TP53 (0.49) | KEAP1NFE2L2MEN1KMT2APOLB | |
| SCHEMBL6600754 | 0.75 | SLC9A1 (0.42) | KEAP1NFE2L2MEN1KMT2ASLC9A1 | |
| SCHEMBL4450211 | 0.74 | SLC9A1 (0.69) | KEAP1NFE2L2MEN1KMT2ASLC9A1 | |
| SCHEMBL6600449 | 0.74 | SLC9A1 (0.61) | SLC9A1SLC9A2 | |
| Hydrochloric Acid SCHEMBL6314762 | 0.73 | SLC9A1 (0.67) | KEAP1NFE2L2MEN1KMT2ASLC9A1 | |
| SCHEMBL4450205 | 0.73 | SLC9A1 (0.48) | KEAP1NFE2L2MEN1KMT2ASLC9A1 | |
| Hydrochloric Acid SCHEMBL6321496 | 0.73 | SLC9A1 (0.66) | KEAP1NFE2L2MEN1KMT2ASLC9A1 | |
| Hydrochloric Acid SCHEMBL6314755 | 0.73 | SLC9A1 (0.48) | KEAP1NFE2L2MEN1KMT2ASLC9A1 | |
| SCHEMBL7360447 | 0.72 | KEAP1 (0.53) | KEAP1NFE2L2KMT2ASLC9A1SLC9A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056729-B1 | N-[(SUBSTITUTED FIVE-MEMBERED DI- OR TRIAZA DIUNSATURATED RING)CARBONYL]GUANIDINE DERIVATIVES FOR THE TREATMENT OF ISCHEMIA | PFIZER PROD INC (US) | 2004-12-29 | — | — | EP | claimed |