Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 3/20 | 0.42 |
| ▸ | SLC9A2 | Q9UBY0 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600449 | 0.83 | SLC9A1 (0.61) | SLC9A1SLC9A2OPRM1OPRD1OPRK1 | |
| SCHEMBL6312945 | 0.83 | NFE2L2 (0.57) | SLC9A1SLC9A2OPRM1OPRD1OPRK1 | |
| SCHEMBL27523940 | 0.77 | SLC9A1 (0.43) | SLC9A1SLC9A2OPRM1OPRD1OPRK1 | |
| SCHEMBL6320770 | 0.77 | TP53 (0.48) | SLC9A1SLC9A2OPRM1OPRD1OPRK1 | |
| SCHEMBL4451940 | 0.75 | SLC9A1 (0.73) | SLC9A1SLC9A2OPRM1OPRD1OPRK1 | |
| SCHEMBL6597293 | 0.75 | KEAP1 (0.41) | SLC9A1SLC9A2POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL4451936 | 0.74 | SLC9A1 (0.52) | SLC9A1SLC9A2OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL6314615 | 0.74 | SLC9A1 (0.74) | SLC9A1SLC9A2OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL6314605 | 0.74 | SLC9A1 (0.52) | SLC9A1SLC9A2OPRM1OPRD1OPRK1 | |
| SCHEMBL3415803 | 0.70 | LMNA (0.71) | LMNAMETAP2METAP1HDAC6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056729-B1 | N-[(SUBSTITUTED FIVE-MEMBERED DI- OR TRIAZA DIUNSATURATED RING)CARBONYL]GUANIDINE DERIVATIVES FOR THE TREATMENT OF ISCHEMIA | PFIZER PROD INC (US) | 2004-12-29 | — | — | EP | claimed |