Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HMGCR | P04035 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6597415 | 1.00 | PDE3B (0.44) | PDE3BPDE3AKDM4EALDH1A1MAPT | |
| SCHEMBL6661728 | 0.83 | TNF (0.39) | PDE3BPDE3AKDM4EALDH1A1MAPT | |
| SCHEMBL6664825 | 0.83 | TNF (0.39) | PDE3BPDE3AKDM4EALDH1A1MAPT | |
| SCHEMBL6589679 | 0.81 | KDM4E (0.63) | PDE3BPDE3AKDM4EALDH1A1MAPT | |
| SCHEMBL6589681 | 0.81 | KDM4E (0.63) | PDE3BPDE3AKDM4EALDH1A1MAPT | |
| SCHEMBL6692166 | 0.80 | KMT2A (0.39) | PDE3BPDE3AKDM4EALDH1A1MAPT | |
| SCHEMBL6593976 | 0.77 | TNF (0.35) | PDE3BPDE3AKDM4EALDH1A1MAPT | |
| SCHEMBL6593981 | 0.77 | TNF (0.35) | PDE3BPDE3AKDM4EALDH1A1MAPT | |
| SCHEMBL6665608 | 0.76 | KDM4E (0.55) | PDE3BPDE3AKDM4EALDH1A1MAPT | |
| SCHEMBL6665807 | 0.76 | KDM4E (0.55) | PDE3BPDE3AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389461-A1 | Pyrimidones with antiviral properties | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2004-02-18 | — | — | EP | claimed |
| WO-2004016271-A1 | PYRIMIDONES AS ANTIVIRAL AGENTS | AXXIMA PHARMACEUTICALS AG (DE) | 2004-02-26 | — | — | WO | disclosed |
| EP-1389461-A1 | Pyrimidones with antiviral properties | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2004-02-18 | — | — | EP | disclosed |