Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.45 |
| ▸ | GUSB | P08236 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886533 | 0.81 | TNKS2 (0.56) | RAB9AKDM4EALDH1A1TNKS2KMT2A | |
| SCHEMBL6004217 | 0.80 | TNKS2 (0.51) | RAB9ATNKS2KMT2APARP1HCAR2 | |
| SCHEMBL28502323 | 0.77 | HCAR2 (0.53) | RAB9ATNKS2KMT2APARP1HCAR2 | |
| Hydrochloric Acid SCHEMBL15742407 | 0.76 | KDM4C (0.65) | RAB9AKDM4EALDH1A1TNKS2MEN1 | |
| SCHEMBL28503293 | 0.76 | PARP1 (0.59) | RAB9AALDH1A1TNKS2KMT2APARP1 | |
| SCHEMBL8708547 | 0.75 | KMT2A (0.42) | RAB9AKDM4ETNKS2MEN1KMT2A | |
| SCHEMBL6473755 | 0.74 | KDM4C (0.75) | RAB9ATNKS2KMT2APARP1HCAR2 | |
| SCHEMBL148952 | 0.73 | TNKS2 (0.61) | RAB9AKDM4EALDH1A1TNKS2PARP1 | |
| SCHEMBL31070299 | 0.73 | TNKS2 (0.61) | RAB9AKDM4EALDH1A1TNKS2PARP1 | |
| SCHEMBL38651228 | 0.72 | HTR3A (0.56) | KDM4EALDH1A1TNKS2PARP1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458394-A1 | USE OF OXINDOLE DERIVATIVES IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3 | AstraZeneca AB (SE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055492-A1 | USE OF OXINDOLE DERIVATIVES IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER'S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3 | ASTRAZENECA AB (SE) | 2003-07-10 | — | — | WO | disclosed |