SCHEMBL6599124

SCHEMBL6599124

CC(C)(C)c1csc(-c2cc3cc(Cn4cc(CC(=O)O)c5cc(O)ccc54)ccc3o2)n1

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PLA2G2A P14555 3/20 0.42
CYP26A1 O43174 1/20 0.39
CYP26B1 Q9NR63 1/20 0.39
ICMT O60725 9/20 0.37
PPARD Q03181 4/20 0.36
PPARG P37231 3/20 0.36
PPARA Q07869 3/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
THRA P10827 1/20 0.33
THRB P10828 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8470607 0.99 PLA2G2A (0.42) PLA2G2ACYP26A1CYP26B1ICMTPPARD
Hydrochloric Acid SCHEMBL6598688 0.92 CYP26A1 (0.38) PLA2G2ACYP26A1CYP26B1PPARDPPARG
SCHEMBL6599665 0.91 PLA2G2A (0.39) PLA2G2ACYP26A1CYP26B1ICMTPPARD
SCHEMBL6598493 0.91 ALDH1A1 (0.46) PLA2G2ACYP26A1CYP26B1ICMTPPARD
SCHEMBL6601187 0.90 PLA2G2A (0.49) PLA2G2ACYP26A1CYP26B1ICMTPPARD
SCHEMBL8624729 0.88 THRA (0.46) PLA2G2AICMTPPARDPPARGPPARA
SCHEMBL5810419 0.88 PPARD (0.53) PLA2G2AICMTPPARDPPARGPPARA
SCHEMBL5813459 0.87 PLA2G2A (0.33) PLA2G2ACYP26A1CYP26B1THRATHRB
SCHEMBL5809194 0.86 THRA (0.41) PLA2G2AICMTPPARDPPARGPPARA
SCHEMBL6599833 0.86 PLA2G2A (0.47) PLA2G2AICMTPPARDPPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1170009-B1 Thiazolybenzofuran derivatives and their use as SRS-A and leukotiene antagonists FUJISAWA PHARMACEUTICAL CO (JP) 2004-04-07 EP disclosed
EP-1170009-A2 Thiazolybenzofuran derivatives and their use as SRS-A and leukotiene antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-01-09 EP disclosed
US-5994378-A ANTIALLERGENS; ANTIINFLAMMATORY AGENTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
EP-0880519-A1 THIAZOLYLBENZOFURAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-12-02 EP disclosed
WO-1997027190-A1 THIAZOLYLBENZOFURAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-07-31 WO disclosed