Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2251923 | 0.84 | KEAP1 (0.73) | KEAP1NFE2L2CA2SMN1; SMN2UTS2R | |
| SCHEMBL1520186 | 0.83 | KEAP1 (0.68) | KEAP1NFE2L2CA2TP53SMN1; SMN2 | |
| SCHEMBL9751552 | 0.82 | CA2 (0.56) | KEAP1NFE2L2CA2TP53SMN1; SMN2 | |
| SCHEMBL9314600 | 0.79 | CA2 (0.53) | KEAP1NFE2L2CA2TP53SMN1; SMN2 | |
| SCHEMBL5179133 | 0.79 | CA2 (0.55) | KEAP1NFE2L2CA2TP53SMN1; SMN2 | |
| SCHEMBL2248697 | 0.78 | CYP2A6 (0.58) | KEAP1NFE2L2CA2TP53SMN1; SMN2 | |
| SCHEMBL19627156 | 0.78 | CA2 (0.49) | KEAP1NFE2L2CA2TP53SMN1; SMN2 | |
| SCHEMBL10266973 | 0.77 | CA2 (0.60) | KEAP1NFE2L2CA2TP53MTNR1A | |
| SCHEMBL5267734 | 0.76 | CYP2A6 (0.58) | KEAP1NFE2L2CA2TP53SMN1; SMN2 | |
| SCHEMBL5267998 | 0.76 | LMNA (0.54) | KEAP1NFE2L2CA2TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337528-B1 | BENZOTHIOPHENE DERIVATIVE COMPOUNDS, PROCESS OF PREPARATION AND USE THEREOF | VITA LAB (ES) | 2004-08-04 | — | — | EP | disclosed |