Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133921 | 0.77 | KDM4E (0.44) | KDM4EMAPTRECQLKMT2AMEN1 | |
| SCHEMBL2175860 | 0.75 | GABRA1 (0.32) | KDM4E | |
| SCHEMBL9908382 | 0.75 | CA12 (0.37) | KDM4EMAPTRECQLKMT2AMEN1 | |
| SCHEMBL19438349 | 0.74 | ALDH1A1 (0.32) | KMT2AALDH1A1HPGD | |
| SCHEMBL20528659 | 0.74 | AHR (0.37) | KDM4EKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL485902 | 0.73 | LMNA (0.37) | KDM4EMAPTRECQLKMT2AMEN1 | |
| SCHEMBL2222860 | 0.73 | LMNA (0.34) | KDM4EMAPTRECQLKMT2AMEN1 | |
| SCHEMBL4378015 | 0.73 | MEN1 (0.36) | KDM4EMAPTRECQLKMT2AMEN1 | |
| SCHEMBL6477427 | 0.73 | LOXL2 (0.33) | KDM4EMAPTRECQLKMT2AMEN1 | |
| SCHEMBL7504628 | 0.72 | ALDH1A1 (0.40) | KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440078-A1 | HETEROCYCLIC GPR119 AGONIST COMPOUNDS | MANKIND PHARMA LTD (IN) | 2019-02-13 | — | — | EP | disclosed |
| WO-2017175066-A1 | HETEROCYCLIC GPR119 AGONIST COMPOUNDS | MANKIND PHARMA LTD. (IN) | 2017-10-12 | — | — | WO | disclosed |
| EP-1432697-A1 | PYRIDYLFURANS AND PYRROLES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003022833-A1 | PYRIDYLFURANS AND PYRROLES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2003-03-20 | — | — | WO | disclosed |