SCHEMBL6600592

SCHEMBL6600592

COC(=O)c1cc(Cl)c(NC(C)=O)c2c1OCC2

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HTR4 Q13639 2/20 0.38
KDM4E B2RXH2 2/20 0.38
HTR1A P08908 1/20 0.38
ADRA2C P18825 1/20 0.38
ACHE P22303 1/20 0.38
PTGS1 P23219 1/20 0.38
ADRA1A P35348 1/20 0.38
HTR3A P46098 1/20 0.38
KCNH2 Q12809 1/20 0.38
MAPK1 P28482 1/20 0.38
ALDH1A1 P00352 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.36
GAA P10253 1/20 0.36
MEN1 O00255 1/20 0.35
LMNA P02545 1/20 0.35
KMT2A Q03164 1/20 0.35
NQO2 P16083 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8690082 0.93 KDM4E (0.37) HTR4KDM4EHTR1AADRA2CADRA1A
SCHEMBL7325147 0.91 ALDH1A1 (0.36) KDM4EACHEMAPK1ALDH1A1SMN1; SMN2
SCHEMBL8500298 0.88 HTR4 (0.36) HTR4KDM4EHTR1AADRA2CACHE
SCHEMBL6586553 0.87 KDM4E (0.41) HTR4KDM4EHTR1AADRA2CACHE
SCHEMBL19211613 0.86 KDM4E (0.40) HTR4KDM4EHTR1AADRA2CACHE
SCHEMBL19211614 0.85 HTR4 (0.34) HTR4KDM4EHTR1AADRA2CACHE
SCHEMBL30732410 0.85 HTR4 (0.34) HTR4KDM4EHTR1AADRA2CACHE
SCHEMBL28430693 0.85 HTR4 (0.39) HTR4HTR1AADRA2CACHEPTGS1
SCHEMBL28427231 0.85 KDM4E (0.36) HTR4KDM4EMAPK1ALDH1A1SMN1; SMN2
SCHEMBL8132698 0.81 MAPK1 (0.36) KDM4EMAPK1ALDH1A1SMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114437007-B Preparation method of prizepride intermediate 鲁南制药集团股份有限公司 2024-03-19 CN claimed
EP-3413891-B1 PROCESSES FOR THE PREPARATION OF HIGHLY PURE PRUCALOPRIDE SUCCINATE SYMED LABS LTD (IN) 2024-01-03 EP claimed
CN-115745928-A Preparation method of prucalopride intermediate 山东新时代药业有限公司 2023-03-07 CN claimed
CN-114591278-A Preparation method of 4-acetamido-5-chloro-2, 3-dihydrobenzofuran-7-carboxylic acid methyl ester 鲁南制药集团股份有限公司 2022-06-07 CN claimed
CN-114437007-A Preparation method of prucalopride intermediate 鲁南制药集团股份有限公司 2022-05-06 CN claimed
EP-3413891-A1 PROCESSES FOR THE PREPARATION OF HIGHLY PURE PRUCALOPRIDE SUCCINATE AND ITS INTERMEDIATES Symed Labs Limited (IN) 2018-12-19 EP claimed
WO-2017137910-A1 PROCESSES FOR THE PREPARATION OF HIGHLY PURE PRUCALOPRIDE SUCCINATE AND ITS INTERMEDIATES SYMED LABS LIMITED (IN) 2017-08-17 WO claimed
CN-115745928-B Prucalopride Process for the preparation of intermediates 山东新时代药业有限公司 2025-11-18 CN disclosed
CN-114437007-B Preparation method of prizepride intermediate 鲁南制药集团股份有限公司 2024-03-19 CN disclosed
CN-114437007-B Preparation method of prizepride intermediate 鲁南制药集团股份有限公司 2024-03-19 CN disclosed
EP-3413891-B1 PROCESSES FOR THE PREPARATION OF HIGHLY PURE PRUCALOPRIDE SUCCINATE SYMED LABS LTD (IN) 2024-01-03 EP disclosed
CN-116082319-A Continuous synthesis method of prucalopride succinate 南京恒通医药开发有限公司 2023-05-09 CN disclosed
CN-115745928-A Preparation method of prucalopride intermediate 山东新时代药业有限公司 2023-03-07 CN disclosed
WO-2017137910-A1 PROCESSES FOR THE PREPARATION OF HIGHLY PURE PRUCALOPRIDE SUCCINATE AND ITS INTERMEDIATES SYMED LABS LIMITED (IN) 2017-08-17 WO disclosed
WO-2017137910-A1 PROCESSES FOR THE PREPARATION OF HIGHLY PURE PRUCALOPRIDE SUCCINATE AND ITS INTERMEDIATES SYMED LABS LIMITED (IN) 2017-08-17 WO disclosed
WO-2017137910-A1 PROCESSES FOR THE PREPARATION OF HIGHLY PURE PRUCALOPRIDE SUCCINATE AND ITS INTERMEDIATES SYMED LABS LIMITED (IN) 2017-08-17 WO disclosed
EP-1076055-B1 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS DAINIPPON PHARMACEUTICAL CO (JP) 2004-11-24 EP disclosed
US-6294555-B1 SEROTONIN HT3 RECEPTOR ANTAGONIST FOR GASTROINTESTINAL DISORDERS DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 2001-09-25 US disclosed
EP-1076055-A1 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS Dainippon Pharmaceutical Co., Ltd. (JP) 2001-02-14 EP disclosed
US-5459161-A Cognition activators FARMITALIA CARLO ERBA S.R.L. (IT) 1995-10-17 US disclosed