Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.45 |
| ▸ | CTSL | P07711 | 5/20 | 0.45 |
| ▸ | CTSB | P07858 | 4/20 | 0.45 |
| ▸ | CTSK | P43235 | 5/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 5/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604451 | 0.83 | CTSS (0.44) | CTSSCTSLCTSBCTSKPDE4B | |
| SCHEMBL6600419 | 0.82 | CTSK (0.44) | CTSSCTSLCTSBCTSKFKBP1A | |
| SCHEMBL30804803 | 0.78 | KLK7 (0.48) | CTSLCTSBCTSKFKBP1AKMT2A | |
| SCHEMBL27512771 | 0.78 | CTSK (0.57) | CTSSCTSLCTSBCTSK | |
| SCHEMBL27978282 | 0.77 | FKBP1A (0.52) | CTSSCTSLCTSBCTSKFKBP1A | |
| SCHEMBL1449131 | 0.77 | CTSL (0.47) | CTSSCTSLCTSBPDE4BKMT2A | |
| SCHEMBL29080198 | 0.76 | CTSL (0.46) | CTSSCTSLCTSBCTSKPDE4B | |
| SCHEMBL30860130 | 0.75 | CTSL (0.46) | CTSSCTSLCTSBCTSKPDE4B | |
| SCHEMBL30793744 | 0.75 | CTSL (0.45) | CTSSCTSLCTSBCTSKPDE4B | |
| SCHEMBL550418 | 0.75 | CTSL (0.56) | CTSSCTSLCTSBCTSKKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392657-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-03-10 | — | — | EP | disclosed |
| EP-1392657-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2003053331-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-07-03 | — | — | WO | disclosed |