Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | JAK1 | P23458 | 4/20 | 0.47 |
| ▸ | TYK2 | P29597 | 4/20 | 0.47 |
| ▸ | JAK3 | P52333 | 4/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | GLS | O94925 | 13/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.39 |
| ▸ | ITGA2 | P17301 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4651945 | 0.76 | BACE1 (0.53) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL4651177 | 0.75 | JAK2 (0.45) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL29925758 | 0.71 | GSK3B (0.46) | — | |
| SCHEMBL27031908 | 0.71 | GSK3B (0.46) | — | |
| SCHEMBL3294238 | 0.70 | — | — | |
| SCHEMBL6614928 | 0.70 | GLS (0.39) | GLSITGB1ITGA2 | |
| SCHEMBL14084714 | 0.66 | CCNC (0.40) | GLSITGB1ITGA2 | |
| SCHEMBL4534502 | 0.66 | GLS (0.42) | JAK2JAK1TYK2JAK3ALK | |
| SCHEMBL7252376 | 0.66 | CRBN (0.67) | — | |
| SCHEMBL4530284 | 0.65 | GLS (0.41) | JAK2JAK1TYK2JAK3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395257-A1 | MACROCYCLES USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-03-10 | — | — | EP | disclosed |