Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 8/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.32 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.32 |
| ▸ | RYR1 | P21817 | 4/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21067920 | 0.74 | CTSD (0.47) | — | |
| SCHEMBL6601775 | 0.70 | JAK2 (0.47) | GLSITGB1ITGA2 | |
| SCHEMBL28729362 | 0.67 | CRBN (0.76) | CRBNFKBP5OR51E2 | |
| SCHEMBL21473988 | 0.67 | OR51E2 (0.79) | CRBNFKBP5OR51E2 | |
| SCHEMBL16431244 | 0.67 | OR51E2 (0.79) | CRBNFKBP5OR51E2 | |
| SCHEMBL575814 | 0.67 | CRBN (0.65) | CRBNFKBP5OR51E2 | |
| SCHEMBL27172945 | 0.67 | CRBN (0.65) | CRBNFKBP5OR51E2 | |
| SCHEMBL1185759 | 0.67 | — | — | |
| SCHEMBL7252376 | 0.67 | CRBN (0.67) | CRBNFKBP5OR51E2CA1CA9 | |
| SCHEMBL13171775 | 0.66 | GLS (0.37) | GLSCA1CA9ITGB1ITGA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404671-A1 | MACROCYCLES USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-04-07 | — | — | EP | disclosed |
| WO-2002100856-A1 | MACROCYCLES USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-12-19 | — | — | WO | disclosed |