SCHEMBL6559596

SCHEMBL6559596

Cc1cc2c(cc1C)C(N(C)S(C)(=O)=O)CC(C)(C)O2

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KCNE1 P15382 4/20 0.36
KCNQ1 P51787 4/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6558662 0.86 KCNE1 (0.39) KCNE1KCNQ1
SCHEMBL6602008 0.80 KCNE1 (0.44) KCNE1KCNQ1
SCHEMBL6560005 0.78 KCNE1 (0.43) KCNE1KCNQ1
SCHEMBL6559540 0.77 KCNE1 (0.33) KCNE1KCNQ1
SCHEMBL6559947 0.77 KCNE1 (0.51) KCNE1KCNQ1
SCHEMBL6560808 0.76 KCNE1 (0.41) KCNE1KCNQ1
SCHEMBL6559277 0.74 KCNE1 (0.40) KCNE1KCNQ1
SCHEMBL6559538 0.73 TRPV1 (0.37)
SCHEMBL6559593 0.72 KCNE1 (0.38) KCNE1KCNQ1
SCHEMBL16381656 0.71 HTR2C (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0807629-B1 Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them AVENTIS PHARMA GMBH (DE) 2004-03-03 EP disclosed
US-6191164-B1 POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS HOECHST AKTIENGESELLSCHAFT (DE) 2001-02-20 US disclosed
EP-0807629-A1 Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them HOECHST AKTIENGESELLSCHAFT (DE) 1997-11-19 EP disclosed