SCHEMBL6602069

SCHEMBL6602069

CCCN(CCC)CCOc1cc(N)ccc1OC

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 2/20 0.53
EBP Q15125 1/20 0.53
TMEM97 Q5BJF2 1/20 0.53
KDM4E B2RXH2 2/20 0.51
GAA P10253 2/20 0.51
MAPT P10636 2/20 0.51
MEN1 O00255 1/20 0.47
USP2 O75604 1/20 0.47
ALDH1A1 P00352 1/20 0.47
TP53 P04637 1/20 0.47
POLB P06746 1/20 0.47
CASP1 P29466 1/20 0.47
HTT P42858 1/20 0.47
CASP7 P55210 1/20 0.47
KMT2A Q03164 1/20 0.47
ATM Q13315 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6603753 0.93 SIGMAR1 (0.52) SIGMAR1EBPTMEM97KDM4EGAA
SCHEMBL3616464 0.89 BIRC5 (0.54) SIGMAR1KDM4EGAAMAPTMEN1
SCHEMBL22502189 0.84 MAPT (0.66) KDM4EGAAMAPTMEN1USP2
SCHEMBL12409051 0.83 ALDH1A1 (0.56) SIGMAR1EBPTMEM97KDM4EMAPT
SCHEMBL3859527 0.83 GAA (0.61) SIGMAR1KDM4EGAAMAPTMEN1
SCHEMBL1220219 0.83 HTR7 (0.53) KDM4EGAAMAPTMEN1USP2
SCHEMBL5704645 0.82 GAA (0.59) KDM4EGAAMAPTMEN1USP2
SCHEMBL3865198 0.82 KDM4E (0.49) SIGMAR1EBPTMEM97KDM4EGAA
SCHEMBL12521822 0.81 KDM4E (0.50) SIGMAR1EBPTMEM97KDM4EGAA
SCHEMBL22502366 0.81 GAA (0.57) SIGMAR1KDM4EGAAMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1102535-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2004-09-29 EP disclosed
WO-2004011427-A2 SUBSTITUTED BENZANILIDES AS MODULATORS OF THE CCR5 RECEPTOR SMITHKLINE BEECHAM CORPORATION (US) 2004-02-05 WO disclosed
EP-1001766-B1 COMPOUNDS FOR THE TREATMENT OF CCR5-MEDIATED DISEASES SMITHKLINE BEECHAM CORP (US) 2003-04-09 EP disclosed
US-6515027-B1 Ligands, agonists or antagonists, of the CC chemokine receptor CC-CKR5 SMITHKLINE BEECHAM CORP. 2003-02-04 US disclosed
EP-1102535-A2 COMPOUNDS AND METHODS SmithKline Beecham Corporation (US) 2001-05-30 EP disclosed
EP-1001766-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2001-04-04 EP disclosed
EP-1001766-A1 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-05-24 EP disclosed
WO-2000006085-A2 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-02-10 WO disclosed
WO-1999001127-A1 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 1999-01-14 WO disclosed