Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 9/20 | 0.52 |
| ▸ | DRD2 | P14416 | 8/20 | 0.52 |
| ▸ | HTR1A | P08908 | 7/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5149479 | 0.90 | HTR1A (0.53) | DRD4DRD2HTR1AKCNH2SIGMAR1 | |
| SCHEMBL6589456 | 0.83 | HTR1A (0.52) | DRD4DRD2HTR1AKCNH2SIGMAR1 | |
| SCHEMBL6597710 | 0.83 | PPARG (0.47) | DRD4DRD2HTR1AKCNH2SIGMAR1 | |
| SCHEMBL1138642 | 0.83 | DRD4 (0.52) | DRD4DRD2HTR1AKCNH2SIGMAR1 | |
| SCHEMBL6586330 | 0.83 | HTR1A (0.52) | DRD4DRD2HTR1AKCNH2SIGMAR1 | |
| SCHEMBL3453155 | 0.82 | DRD4 (0.52) | DRD4DRD2HTR1AKCNH2SIGMAR1 | |
| SCHEMBL27477227 | 0.82 | DRD2 (0.40) | DRD4DRD2KCNH2SIGMAR1HTR6 | |
| SCHEMBL6608875 | 0.80 | PARP1 (0.50) | DRD4DRD2HTR1ASIGMAR1HTR6 | |
| SCHEMBL21662053 | 0.76 | DRD4 (0.64) | DRD4DRD2HTR1AKCNH2SIGMAR1 | |
| SCHEMBL6598869 | 0.76 | PPARG (0.47) | DRD4DRD2KCNH2SIGMAR1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226137-B8 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI AVENTIS (FR) | 2004-12-15 | — | — | EP | disclosed |
| EP-1226137-B1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI SYNTHELABO (FR) | 2004-07-21 | — | — | EP | disclosed |
| EP-1226137-A1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI-SYNTHELABO (FR) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001029026-A1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI-SYNTHELABO (FR) | 2001-04-26 | — | — | WO | disclosed |