SCHEMBL6602254

SCHEMBL6602254

Cc1noc([C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)C=CC(C)(C)NC(=O)OC(C)(C)C)n1

nearest known ligand 0.43

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 7/20 0.43
CTSB P07858 1/20 0.37
CTSS P25774 1/20 0.37
CTSK P43235 1/20 0.37
PSMB5 P28074 1/20 0.32
MMP9 P14780 1/20 0.32
MMP8 P22894 1/20 0.32
PPIA P62937 1/20 0.32
PTPN1 P18031 1/20 0.32
MME P08473 1/20 0.30
ACE P12821 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6602251 1.00 GHSR (0.43) GHSRCTSBCTSSCTSKPSMB5
SCHEMBL6600520 0.88 CTSB (0.41) GHSRCTSBCTSSCTSKPSMB5
SCHEMBL6600517 0.88 CTSB (0.41) GHSRCTSBCTSSCTSKPSMB5
SCHEMBL6600943 0.86 GHSR (0.48) GHSRPSMB5MMP9MMP8MME
SCHEMBL6600948 0.86 GHSR (0.48) GHSRPSMB5MMP9MMP8MME
SCHEMBL6600092 0.84 GHSR (0.39) GHSRCTSBCTSSCTSKMMP9
SCHEMBL6602009 0.83 GHSR (0.43) GHSRCTSBCTSSCTSK
SCHEMBL6602015 0.83 GHSR (0.43) GHSRCTSBCTSSCTSK
SCHEMBL6320628 0.81 CTSS (0.52) CTSBCTSSCTSKMMP9MMP8
SCHEMBL6603214 0.80 CTSB (0.41) GHSRCTSBCTSSCTSKMMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0805816-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2004-07-28 EP disclosed
US-6350767-B1 GROWTH HORMONE RELEASE STIMULANT NOVO NORDISK A/S (DK) 2002-02-26 US disclosed
US-6013658-A ANIMAL GROWTH REGULATORS NOVO NORDISK A/S (DK) 2000-01-11 US disclosed