SCHEMBL6603098

SCHEMBL6603098

CCCN(CCC)CCOc1cc(NC(=O)c2cncc(Br)c2)ccc1OC

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 2/20 0.52
SMN1; SMN2 Q16637 7/20 0.52
HTT P42858 4/20 0.52
NPC1 O15118 3/20 0.52
RAB9A P51151 3/20 0.52
MAPT P10636 2/20 0.52
MAPK1 P28482 2/20 0.52
TSHR P16473 1/20 0.52
LMNA P02545 1/20 0.52
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
KMT2A Q03164 3/20 0.49
MEN1 O00255 2/20 0.49
PDE4A P27815 1/20 0.48
PDE4B Q07343 1/20 0.48
PDE4C Q08493 1/20 0.48
PDE4D Q08499 1/20 0.48
ALDH1A1 P00352 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7723668 0.93 MCHR1 (0.61) MCHR1SMN1; SMN2HTTNPC1RAB9A
SCHEMBL6606694 0.90 MCHR1 (0.58) MCHR1SMN1; SMN2HTTNPC1RAB9A
SCHEMBL6603095 0.87 MCHR1 (0.60) MCHR1SMN1; SMN2HTTNPC1RAB9A
SCHEMBL6606159 0.86 ALDH1A1 (0.56) MCHR1SMN1; SMN2HTTNPC1RAB9A
SCHEMBL6602556 0.85 CHRNB4 (0.51) MCHR1SMN1; SMN2RAB9AMAPTPDE4A
SCHEMBL6604498 0.82 MCHR1 (0.55) MCHR1SMN1; SMN2HTTNPC1RAB9A
SCHEMBL6602569 0.82 MCHR1 (0.65) MCHR1MAPTMAPK1CYP1A2CYP3A4
SCHEMBL6925370 0.81 MCHR1 (0.71) MCHR1SMN1; SMN2NPC1RAB9AMAPT
SCHEMBL6605156 0.81 MCHR1 (0.65) MCHR1MAPTLMNAROCK2
SCHEMBL6898088 0.80 MCHR1 (0.67) MCHR1SMN1; SMN2NPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1102535-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2004-09-29 EP claimed
EP-1102535-A2 COMPOUNDS AND METHODS SmithKline Beecham Corporation (US) 2001-05-30 EP claimed
WO-2000006085-A2 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-02-10 WO claimed
EP-1102535-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2004-09-29 EP disclosed
EP-1102535-A2 COMPOUNDS AND METHODS SmithKline Beecham Corporation (US) 2001-05-30 EP disclosed
WO-2000006085-A2 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-02-10 WO disclosed