Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | MITF | O75030 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602204 | 0.94 | ALDH1A1 (0.36) | ALDH1A1MITFHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL6604561 | 0.91 | ALDH1A1 (0.39) | ALDH1A1MITFHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL6605470 | 0.86 | ALDH1A1 (0.34) | ALDH1A1MITFHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL6601960 | 0.83 | KMT2A (0.41) | ALDH1A1MITFHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL6602436 | 0.83 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2LMNAPOLBMAPT | |
| SCHEMBL6603788 | 0.82 | ALDH1A1 (0.38) | ALDH1A1MITFHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL6603403 | 0.81 | MAPT (0.32) | ALDH1A1MITFHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL6603385 | 0.81 | KMT2A (0.40) | ALDH1A1MITFHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL6602557 | 0.81 | KMT2A (0.38) | ALDH1A1MITFHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL6603316 | 0.79 | ALDH1A1 (0.45) | ALDH1A1MITFHPGDSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020453-B1 | 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERIVATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN SEIYAKU KK (JP) | 2004-05-19 | — | — | EP | disclosed |
| US-6348461-B1 | CENTRAL NERVOUS SYSTEM ANTAGONIST WITH HETEROCYCLIC SUBSTITUENTS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-02-19 | — | — | US | disclosed |
| EP-1020453-A1 | 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERI VATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |