Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6596709 | 0.83 | ALDH1A1 (0.47) | KMT2AOPRK1MEN1ALDH1A1HTT | |
| SCHEMBL3763346 | 0.81 | LMNA (0.58) | KMT2AOPRK1APEX1MEN1ALDH1A1 | |
| SCHEMBL6599742 | 0.81 | ALDH1A1 (0.46) | KMT2AOPRK1APEX1MEN1ALDH1A1 | |
| SCHEMBL30894837 | 0.80 | KMT2A (0.55) | KMT2AOPRK1APEX1MEN1ALDH1A1 | |
| SCHEMBL4658369 | 0.80 | KMT2A (0.55) | KMT2AOPRK1APEX1MEN1ALDH1A1 | |
| SCHEMBL6605853 | 0.78 | KMT2A (0.50) | KMT2AOPRK1APEX1MEN1ALDH1A1 | |
| SCHEMBL17478740 | 0.78 | KMT2A (0.52) | KMT2AOPRK1APEX1MEN1ALDH1A1 | |
| SCHEMBL30894828 | 0.77 | ALDH1A1 (0.53) | KMT2AOPRK1APEX1MEN1ALDH1A1 | |
| SCHEMBL6204514 | 0.75 | KDM4E (0.50) | KMT2AOPRK1APEX1MEN1NPBWR1 | |
| SCHEMBL6534272 | 0.74 | ELANE (0.64) | KMT2AOPRK1MEN1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373252-A1 | CHEMICAL DERIVATIVES AND THEIR USE AS ANTI-TELOMERASE AGENT | Aventis Pharma S.A. (FR) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002076975-A1 | CHEMICAL DERIVATIVES AND THEIR USE AS ANTI-TELOMERASE AGENT | AVENTIS PHARMA S.A. (FR) | 2002-10-03 | — | — | WO | disclosed |