Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ME2 | P23368 | 1/20 | 0.42 |
| ▸ | ME1 | P48163 | 1/20 | 0.42 |
| ▸ | ME3 | Q16798 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604084 | 0.86 | MC4R (0.46) | MC4R | |
| SCHEMBL4678279 | 0.83 | MC4R (0.54) | MC4R | |
| SCHEMBL4678276 | 0.78 | MC4R (0.41) | MC4R | |
| SCHEMBL6602536 | 0.76 | MC4R (0.69) | MC4RKMT2AUSP2LMNA | |
| SCHEMBL4679456 | 0.75 | MC4R (0.59) | MC4R | |
| SCHEMBL6603967 | 0.68 | KMT2A (0.57) | MC4RKMT2AMEN1MAPTUSP2 | |
| SCHEMBL2824683 | 0.67 | MAPT (1.00) | KMT2AMEN1MAPTLMNAME2 | |
| SCHEMBL13504053 | 0.67 | SMN1; SMN2 (0.69) | KMT2AMEN1MAPTLMNAME2 | |
| SCHEMBL13503947 | 0.66 | MEN1 (0.62) | KMT2AMEN1MAPTLMNAME2 | |
| SCHEMBL13504080 | 0.66 | FKBP1A (0.53) | MC4RKMT2AMEN1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgen Inc. (US) | 2004-05-12 | — | — | EP | claimed |
| WO-2003009850-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC. (US) | 2003-02-06 | — | — | WO | claimed |