Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 6/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | KLK1 | P06870 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 3/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609734 | 0.90 | PDE4D (0.35) | PDE4DPDE4BPDE4APDE4CBRD4 | |
| SCHEMBL6608204 | 0.84 | ALDH1A1 (0.36) | PDE4DMEN1KMT2ABRD4HTT | |
| SCHEMBL6607492 | 0.77 | PDE4A (0.42) | PDE4DPDE4BPDE4APDE4CMEN1 | |
| SCHEMBL6606553 | 0.73 | PDE4D (0.49) | PDE4DPDE4BPDE4APDE4CF2 | |
| SCHEMBL6605529 | 0.70 | F2 (0.42) | PDE4DPDE4BPDE4APDE4CF2 | |
| SCHEMBL7017344 | 0.69 | PDE4A (0.52) | PDE4DPDE4BPDE4APDE4CHTR6 | |
| SCHEMBL5964204 | 0.68 | PDE4D (0.56) | PDE4DPDE4BPDE4APDE4CHTT | |
| SCHEMBL6604220 | 0.68 | KDM4E (0.41) | PDE4DPDE4BPDE4APDE4CMEN1 | |
| SCHEMBL6614123 | 0.67 | ALDH1A1 (0.38) | PDE4DPDE4BPDE4APDE4CMEN1 | |
| SCHEMBL7017103 | 0.66 | PDE4D (0.53) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257548-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2004-05-06 | — | — | EP | claimed |