⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27394165 | 0.83 | — | — | |
| SCHEMBL4244197 | 0.77 | NOS2 (0.43) | — | |
| SCHEMBL9978895 | 0.73 | CES2 (0.47) | — | |
| SCHEMBL9051813 | 0.73 | NOS2 (0.53) | — | |
| SCHEMBL6265136 | 0.73 | CES2 (0.47) | — | |
| SCHEMBL5131 | 0.73 | CES2 (0.47) | — | |
| SCHEMBL5281 | 0.73 | — | — | |
| SCHEMBL1858120 | 0.73 | CES2 (0.47) | — | |
| SCHEMBL673560 | 0.73 | CES2 (0.47) | — | |
| SCHEMBL5411 | 0.73 | CES2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174509-A1 | THERAPEUTIC USE OF PLEUROMUTILINS | ARIVA MED GMBH (AT) | 2023-06-08 | — | — | US | claimed |
| EP-4135683-A1 | THERAPEUTIC USE OF PLEUROMUTILINS | Nabriva Therapeutics GMBH (AT) | 2023-02-22 | — | — | EP | claimed |
| CN-115413238-A | Therapeutic use of pleuromutilin compounds | 纳布里瓦治疗有限责任公司 | 2022-11-29 | — | — | CN | claimed |
| WO-2021209596-A1 | THERAPEUTIC USE OF PLEUROMUTILINS | Nabriva Therapeutics GmbH (AT) | 2021-10-21 | — | — | WO | claimed |
| EP-3096751-B1 | 12-EPI-PLEUROMUTILINS | Nabriva Therapeutics GmbH (AT) | 2021-01-06 | — | — | EP | claimed |
| CN-105916499-B | 12-epi-pleuromutilins | 纳布里瓦治疗股份公司 | 2020-02-18 | — | — | CN | claimed |
| WO-2017189866-A1 | POLYMYXIN ANALOGS USEFUL AS ANTIBIOTIC POTENTIATORS | SPERO OPCO (US) | 2017-11-02 | — | — | WO | claimed |
| US-9701628-B2 | 12-epi pleuromutilins | NABRIVA THERAPEUTICS AG (AT) | 2017-07-11 | — | — | US | claimed |
| EP-3096751-A1 | 12-EPI-PLEUROMUTILINS | Nabriva Therapeutics AG (AT) | 2016-11-30 | — | — | EP | claimed |
| US-20160332963-A1 | 12-EPI PLEUROMUTILINS | Nabriva Therapeutics GmbH (AT) | 2016-11-17 | — | — | US | claimed |
| WO-2015110481-A1 | 12-EPI-PLEUROMUTILINS | NABRIVA THERAPEUTICS AG (AT) | 2015-07-30 | — | — | WO | claimed |
| CN-100396668-C | Non-imidazole aryloxypiperidines | ORTHO MCNEIL PHARM INC (US) | 2008-06-25 | — | — | CN | claimed |
| US-20240208989-A1 | NOVEL 12-EPI-MUTILIN COMPOUNDS AND USES THEREOF | ARIVA MED GMBH (AT) | 2024-06-27 | — | — | US | disclosed |
| EP-4323366-A1 | NOVEL 12-EPI-MUTILIN COMPOUNDS AND USES THEREOF | Nabriva Therapeutics GMBH (AT) | 2024-02-21 | — | — | EP | disclosed |
| CN-117500809-A | Novel 12-epimeric-mollin compounds and uses thereof | 纳布里瓦治疗有限责任公司 | 2024-02-02 | — | — | CN | disclosed |
| US-20230250047-A1 | METHOD FOR ISOMERIZING ALIPHATIC DIAMINE, METHOD FOR PRODUCING DIISOCYANATE, METHOD FOR PRODUCING POLYURETHANE, AND POLYURETHANE | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2023-08-10 | — | — | US | disclosed |
| EP-1106614-A1 | 5-Membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 2001-06-13 | — | — | EP | disclosed |
| CN-1048243-C | Alkylation method of triazine derivative | NISSAN CHEMICAL IND LTD (JP) | 2000-01-12 | — | — | CN | disclosed |
| CN-1147812-A | Alkylation method of triazine derivative | NISSAN CHEMICAL IND LTD (JP) | 1997-04-16 | — | — | CN | disclosed |
| CN-1127506-A | Method of alkylating triazine derivative | NISSAN CHEMICAL IND LTD (JP) | 1996-07-24 | — | — | CN | disclosed |