Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.60 |
| ▸ | RAB9A | P51151 | 10/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | MEN1 | O00255 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL660646 | 1.00 | NPC1 (0.60) | NPC1RAB9AKMT2AMEN1MAPT | |
| Hydrochloric Acid SCHEMBL9388184 | 0.98 | NPC1 (0.58) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL710152 | 0.90 | MAPT (0.55) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL710151 | 0.90 | MAPT (0.55) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL10495647 | 0.84 | RAB9A (0.55) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL10495643 | 0.84 | RAB9A (0.57) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL10495656 | 0.84 | RAB9A (0.57) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL9978289 | 0.84 | MAPT (0.69) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL14935499 | 0.84 | MAPT (0.69) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11049170 | 0.84 | MAPT (0.69) | NPC1RAB9AKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0973741-B1 | S-2'-(2-(1-METHYL-2-PIPERIDYL) ETHYL) CINNAMANILIDE AS A 5-HT2 RECEPTOR ANTAGONIST | AMER M SAMIR (US) | 2003-06-11 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| EP-0973741-A1 | S-2'-(2-(1-METHYL-2-PIPERIDYL) ETHYL) CINNAMANILIDE AS A 5-HT2 RECEPTOR ANTAGONIST | AMER, M. Samir (US) | 2000-01-26 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| WO-1998038165-A1 | S-2'-(2-(1-METHYL-2-PIPERIDYL) ETHYL) CINNAMANILIDE AS A 5-HT2 RECEPTOR ANTAGONIST | AMER MOH SAMIR (US) | 1998-09-03 | — | — | WO | claimed |
| US-5780487-A | INTERMEDIATE FOR SEROTONIN RECEPTOR ANTAGONIST | VENTRUS BIOSCIENCES, INC. | 1998-07-14 | — | — | US | claimed |
| WO-2013070236-A1 | METHODS AND COMPOSITIONS FOR TREATING HEMORRHOIDS WHILE PROVIDING LOCAL ANESTHETIC AND ANTI-INFLAMMATORY EFFECTS | VENTRUS BIOSCIENCES, INC. (US) | 2013-05-16 | — | — | WO | disclosed |
| WO-2012026914-A1 | METHODS AND COMPOSITIONS FOR TREATING INTERNAL AND EXTERNAL HEMORRHOIDS | SAM AMER & CO., INC. (US) | 2012-03-01 | — | — | WO | disclosed |
| US-20120046318-A1 | METHODS AND COMPOSITIONS FOR TREATING INTERNAL AND EXTERNAL HEMORRHOIDS | VENTRUS BIOSCIENCES, INC. | 2012-02-23 | — | — | US | disclosed |
| US-20080300410-A1 | Organic Compounds | PRASHAD MAHAVIR | 2008-12-04 | — | — | US | disclosed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| CN-1203060-C | Pyridine derivatives, compositions and uses thereof | NOVARTIS AG (CH) | 2005-05-25 | — | — | CN | disclosed |
| WO-1998038165-A1 | S-2'-(2-(1-METHYL-2-PIPERIDYL) ETHYL) CINNAMANILIDE AS A 5-HT2 RECEPTOR ANTAGONIST | AMER MOH SAMIR (US) | 1998-09-03 | — | — | WO | disclosed |
| US-5780487-A | INTERMEDIATE FOR SEROTONIN RECEPTOR ANTAGONIST | VENTRUS BIOSCIENCES, INC. | 1998-07-14 | — | — | US | disclosed |
| US-RE30812-E | ANTIARRHTHMIA AGENTS | MEAD JOHNSON & COMPANY (US) | 1981-12-01 | — | — | US | disclosed |
| US-RE30811-E | SEROTONIN ANTAGONISTS, ANTIARRHYTHMIA AGENTS | MEAD JOHNSON & COMPANY (US) | 1981-12-01 | — | — | US | disclosed |
| US-4064254-A | ANTIARRHYTHMIC AND ANTISEROTONINE AGENTS | MEAD JOHNSON & COMPANY (US) | 1977-12-20 | — | — | US | disclosed |
| US-4000143-A | ANTIARRHYTHMIC AND ANTISEROTONIN AGENTS | MEAD JOHNSON & COMPANY (US) | 1976-12-28 | — | — | US | disclosed |
| US-3931195-A | ANTIARRHYTHMIA, ANTISEROTONIN | MEAD JOHNSON & COMPANY (US) | 1976-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300410-A1 | Organic Compounds | C1S, C9, C1R | NPC1 643/4885RAB9A 1413/4885KMT2A 2472/4885 |
| US-20120046318-A1 | METHODS AND COMPOSITIONS FOR TREATING INTERNAL AND EXTERNAL HEMORRHOIDS | APC, P4HA1, EGLN2 | NPC1 4307/4885RAB9A 4499/4885KMT2A 274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.