Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 9/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 7/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607228 | 0.84 | AGTR1 (0.61) | BDKRB1AGTR1AGTR2HTTRAB9A | |
| SCHEMBL6607576 | 0.76 | AGTR1 (0.47) | BDKRB1AGTR1AGTR2MAPT | |
| SCHEMBL2087990 | 0.76 | HTT (0.65) | KDRHTTRAB9ANPSR1MAPT | |
| SCHEMBL6605088 | 0.76 | AGTR1 (0.55) | AGTR1AGTR2MAPT | |
| SCHEMBL4174847 | 0.73 | MAPT (0.56) | KDRHTTRAB9ANPSR1MAPT | |
| SCHEMBL28236466 | 0.73 | KDR (0.62) | KDRHTTRAB9ANPSR1MAPT | |
| SCHEMBL2087947 | 0.71 | HTT (0.56) | BDKRB1KDRHTTRAB9ANPSR1 | |
| SCHEMBL9438606 | 0.71 | SLC33A1 (0.37) | AGTR1AGTR2MAPT | |
| SCHEMBL4171211 | 0.69 | HTT (0.52) | KDRHTTRAB9ANPSR1MAPT | |
| SCHEMBL6612663 | 0.68 | ALDH1A1 (0.68) | HTTRAB9ANPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0829479-B1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-04-14 | — | — | EP | disclosed |
| EP-0588299-B1 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0829479-A1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
| US-5500427-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0588299-A2 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |