Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 10/20 | 0.61 |
| ▸ | AGTR2 | P50052 | 10/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605088 | 0.91 | AGTR1 (0.55) | AGTR1AGTR2MAPTHSD17B10ALDH1A1 | |
| SCHEMBL6607576 | 0.90 | AGTR1 (0.47) | AGTR1AGTR2MAPTHSD17B10ALDH1A1 | |
| SCHEMBL6606486 | 0.84 | BDKRB1 (0.48) | AGTR1AGTR2MAPTNPSR1HTT | |
| SCHEMBL9592562 | 0.78 | AGTR1 (0.74) | AGTR1AGTR2MAPTHSD17B10NPSR1 | |
| SCHEMBL8944112 | 0.77 | AGTR1 (0.62) | AGTR1AGTR2MAPTHSD17B10NPSR1 | |
| SCHEMBL6609133 | 0.76 | AGTR1 (0.58) | AGTR1AGTR2HSD17B10ALDH1A1ALOX15 | |
| SCHEMBL9589254 | 0.75 | AGTR1 (0.64) | AGTR1AGTR2MAPTHSD17B10NPSR1 | |
| SCHEMBL9590363 | 0.75 | AGTR1 (0.68) | AGTR1AGTR2MAPTHSD17B10NPSR1 | |
| SCHEMBL8556846 | 0.74 | AGTR1 (0.50) | AGTR1AGTR2HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL18070888 | 0.72 | AGTR1 (0.61) | AGTR1AGTR2MAPTHSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0829479-B1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-04-14 | — | — | EP | disclosed |
| EP-0588299-B1 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0829479-A1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
| US-5500427-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0588299-A2 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |