Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 14/20 | 0.55 |
| ▸ | AGTR2 | P50052 | 13/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607576 | 0.92 | AGTR1 (0.47) | AGTR1AGTR2CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL6607228 | 0.91 | AGTR1 (0.61) | AGTR1AGTR2CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL6609133 | 0.84 | AGTR1 (0.58) | AGTR1AGTR2CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL8556846 | 0.76 | AGTR1 (0.50) | AGTR1AGTR2CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL6606486 | 0.76 | BDKRB1 (0.48) | AGTR1AGTR2MAPT | |
| SCHEMBL9591685 | 0.74 | AGTR1 (0.71) | AGTR1AGTR2CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL9682946 | 0.70 | AGTR2 (0.65) | AGTR1AGTR2CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL9592562 | 0.68 | AGTR1 (0.74) | AGTR1AGTR2CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL8944112 | 0.67 | AGTR1 (0.62) | AGTR1AGTR2CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL9589254 | 0.67 | AGTR1 (0.64) | AGTR1AGTR2CYP1A2CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0829479-B1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-04-14 | — | — | EP | disclosed |
| EP-0588299-B1 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0829479-A1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |