Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 17/20 | 0.50 |
| ▸ | HTR2A known ✓ | P28223 | 14/20 | 0.50 |
| ▸ | HTR2B known ✓ | P41595 | 8/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6607002 | 1.00 | HTR2C (0.50) | HTR2CHTR2AHTR2BDYRK1ALMNA | |
| Fumaric Acid SCHEMBL6607005 | 0.85 | DYRK1A (0.40) | HTR2CHTR2AHTR2BDYRK1A | |
| Fumaric Acid SCHEMBL6604968 | 0.80 | HTR2C (0.80) | HTR2CHTR2AHTR2BLMNAPMP22 | |
| Fumaric Acid SCHEMBL6604972 | 0.80 | HTR2C (0.80) | HTR2CHTR2AHTR2BLMNAPMP22 | |
| Fumaric Acid SCHEMBL8874855 | 0.79 | HTR2C (0.54) | HTR2CHTR2AHTR2B | |
| Fumaric Acid SCHEMBL8874862 | 0.79 | HTR2C (0.54) | HTR2CHTR2AHTR2B | |
| Fumaric Acid SCHEMBL8873554 | 0.79 | HTR2C (0.54) | HTR2CHTR2AHTR2B | |
| Fumaric Acid SCHEMBL8873561 | 0.79 | HTR2C (0.54) | HTR2CHTR2AHTR2B | |
| Fumaric Acid SCHEMBL6602929 | 0.78 | HTR2A (0.80) | HTR2CHTR2AHTR2B | |
| Fumaric Acid SCHEMBL6602840 | 0.78 | HTR2A (0.80) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109809-B1 | PYRROLOQUINOLINES FOR TREATMENT OF OBESITY | CEREBRUS PHARM LTD (GB) | 2004-11-17 | — | — | EP | disclosed |
| US-6365598-B1 | FOR THERAPY AND PROPHYLAXIS OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM; DAMAGE TO THE CENTRAL NERVOUS SYSTEM; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; DIABETES INSIPIDUS; AND SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2002-04-02 | — | — | US | disclosed |