Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5831275 | 0.79 | ALDH1A1 (0.48) | ALDH1A1MAPTNPC1RAB9ATP53 | |
| SCHEMBL5830173 | 0.73 | HPGD (0.55) | ALDH1A1MAPTHPGDTSHRL3MBTL1 | |
| SCHEMBL9213288 | 0.72 | ALDH1A1 (0.50) | IP6K1ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL3883363 | 0.72 | MAPT (0.61) | ALDH1A1MAPTNPC1RAB9AHSD17B10 | |
| SCHEMBL4767629 | 0.71 | NPC1 (0.61) | ALDH1A1MAPTNPC1RAB9AHSD17B10 | |
| SCHEMBL6485292 | 0.71 | ALDH1A1 (0.44) | ALDH1A1MAPTNPC1RAB9AHSD17B10 | |
| SCHEMBL4873981 | 0.71 | NPC1 (0.61) | ALDH1A1MAPTNPC1RAB9AHSD17B10 | |
| SCHEMBL1397421 | 0.71 | NPC1 (0.61) | ALDH1A1MAPTNPC1RAB9AHSD17B10 | |
| SCHEMBL5830139 | 0.70 | HPGD (0.50) | ALDH1A1HSD17B10HPGDSMN1; SMN2LMNA | |
| SCHEMBL4730136 | 0.69 | F10 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465864-A1 | INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE | Warner-Lambert Company LLC (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003045912-A1 | INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE | WARNER-LAMBERT COMPANY LLC (US) | 2003-06-05 | — | — | WO | disclosed |