Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 17/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438362 | 0.78 | F10 (0.41) | F10SYKKLKB1CA12CA1 | |
| SCHEMBL4238560 | 0.75 | F10 (0.58) | F10 | |
| SCHEMBL1226597 | 0.73 | CYP1A2 (0.37) | F10CA12CA1CA2CA9 | |
| SCHEMBL6589321 | 0.71 | KDM4E (0.44) | SYK | |
| SCHEMBL6607436 | 0.69 | IP6K1 (0.41) | — | |
| SCHEMBL1675566 | 0.68 | CA2 (0.47) | F10CA2 | |
| SCHEMBL1030894 | 0.68 | F10 (0.47) | F10SYKKLKB1 | |
| SCHEMBL6522040 | 0.68 | F10 (0.43) | F10SYKKLKB1 | |
| SCHEMBL4591950 | 0.68 | F10 (0.46) | F10SYKKLKB1 | |
| SCHEMBL3818476 | 0.67 | DGAT1 (0.36) | F10SYKKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951717-A1 | NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF COAGULATION FACTOR XA | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007057317-A1 | NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF COAGULATION FACTOR XA | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-24 | — | — | WO | disclosed |
| US-7030141-B2 | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade | WARNER-LAMBERT COMPANY LLC | 2006-04-18 | — | — | US | disclosed |