Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881240 | 0.92 | GCK (0.34) | CRHR1GCKMCHR1 | |
| SCHEMBL4881459 | 0.92 | CRHR1 (0.33) | CRHR1MCHR1 | |
| SCHEMBL22641245 | 0.74 | PTGS2 (0.48) | — | |
| SCHEMBL4631483 | 0.73 | PTGS2 (0.34) | — | |
| SCHEMBL19446104 | 0.72 | PTGS2 (0.50) | — | |
| SCHEMBL18948308 | 0.71 | PARP1 (0.36) | GCK | |
| SCHEMBL6603590 | 0.69 | MAPT (0.38) | — | |
| SCHEMBL31080248 | 0.68 | CRHR1 (0.40) | CRHR1MCHR1 | |
| SCHEMBL6604032 | 0.67 | TLR8 (0.38) | MCHR1 | |
| SCHEMBL8272903 | 0.66 | ALDH1A1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392302-A1 | 5-SUBSTITUTED-2-ARYLPYRIDINES AS CRF1 MODULATORS | NEUROGEN CORPORATION (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002096421-A1 | 5-SUBSTITUTED-2-ARYLPYRIDINES AS CRF1 MODULATORS | NEUROGEN CORPORATION (US) | 2002-12-05 | — | — | WO | disclosed |