Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 15/20 | 0.37 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.34 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164847 | 0.93 | CREBBP (0.37) | CREBBPEP300MAPK10MLLT3MLLT1 | |
| SCHEMBL6609350 | 0.85 | HSD11B1 (0.36) | CREBBPEP300 | |
| SCHEMBL6164284 | 0.84 | CREBBP (0.36) | CREBBPEP300MAPK10MLLT3MLLT1 | |
| SCHEMBL6611947 | 0.81 | MLLT3 (0.45) | CREBBPEP300MAPK10MLLT3MLLT1 | |
| SCHEMBL6606146 | 0.80 | CREBBP (0.33) | CREBBPEP300 | |
| SCHEMBL6609038 | 0.80 | SLC16A3 (0.34) | CREBBPEP300 | |
| SCHEMBL6165821 | 0.78 | HSD11B1 (0.33) | CREBBPEP300 | |
| SCHEMBL6166837 | 0.78 | MLLT3 (0.42) | CREBBPEP300MAPK10MLLT3MLLT1 | |
| SCHEMBL6635699 | 0.77 | CREBBP (0.35) | CREBBPEP300 | |
| SCHEMBL6164801 | 0.77 | CREBBP (0.44) | CREBBPEP300MAPK10MLLT3MLLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |